解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To assess the influence of microRNA-183 (miR-183) on the migration and invasion of A375 human melanoma cells, an A375 cell line with stable miR-183 overexpression or knockdown was constructed using lentiviral transfection. The change of miR-183 expression in these cells and in non-transfected controls was verified usi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9603
更新日期:2019-01-01 00:00:00
abstract::The transcription factor forkhead box O1 (FOXO1) can be inactivated via its phosphorylation, resulting in suppression of apoptosis. Using immunohistochemistry, the expression of a phosphorylated form of FOXO1 was assessed in upper urinary tract urothelial carcinoma (UUTUC) specimens. Overall, phospho-FOXO1 (p-FOXO1) w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9510
更新日期:2019-01-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) are identified to serve key functions in the progression of various tumors. miR-214 is aberrantly expressed in various types of cancer. In the present study, the function of miR-214 and its feasibility as a potential non-invasive biomarker for patients with prostate cancer (PCa) in a hyperplasi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9522
更新日期:2019-01-01 00:00:00
abstract::Liver cancer, which is the second leading cause of tumor-associated mortality, is of great concern worldwide due to its resistance to chemotherapeutic drugs. Transcatheter arterial chemoembolization (TACE) has previously been used as a treatment for unresectable liver tumors in China; however, the response to TACE tre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9584
更新日期:2019-01-01 00:00:00
abstract::To investigate the prospective roles and the clinicopathological application of microRNA-21-5p (miR-21-5p) in hepatocellular carcinoma (HCC), the present review is based on 24 studies and bioinformatics investigation. Firstly, HCC-associated miR-21-5p data were aggregated from literature databases and two public genom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9627
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to evaluate the curative effect of fludeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT)-guided intensity-modulated radiotherapy (IMRT) for 42 patients with International Federation of Gynecology and Obstetrics (FIGO) stage III/IV ovarian cancer. Between Jan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9601
更新日期:2019-01-01 00:00:00
abstract::MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9594
更新日期:2019-01-01 00:00:00
abstract::Breast cancer (BC) is the most frequently diagnosed malignant tumor in women worldwide, and the development of new molecules associated with BC is essential for the management of this disease. RAS and EF-hand domain-containing (RASEF) encodes the GTPase enzyme that belongs to the Rab family. Although the effects of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9542
更新日期:2018-12-01 00:00:00
abstract::Expression of mineral dust-induced gene (mdig) in lung cancer NCI-H1650 cells was detected to investigate the effects of mdig on proliferation and apoptosis of NCI-H1650 cells. NCI-H1650 lung cancer cells were cultured in vitro. The expression of mdig in NCI-H1650 cells was lowered using ribonucleic acid interference ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9528
更新日期:2018-12-01 00:00:00
abstract::Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9516
更新日期:2018-12-01 00:00:00
abstract::Correlation of xeroderma pigmentosum complementation group F (XPF) expression with gastric cancer and prognosis was investigated. We randomly selected 76 gastric cancer patients who were admitted to the Second People's Hospital of Dezhou City and received treatment, and detected XPF expression in gastric cancer tissue...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9529
更新日期:2018-12-01 00:00:00
abstract::Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable p...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2018.9545
更新日期:2018-12-01 00:00:00
abstract::Management of multinodular hepatocellular carcinoma (HCC) in the intermediate Barcelona Clinic Liver Cancer (BCLC)-B stage is controversial. The aim of the present study as to identify the subgroup of patients with BCLC-B HCC who could benefit from liver resection. The present study retrospectively analyzed the outcom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9420
更新日期:2018-11-01 00:00:00
abstract::Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9358
更新日期:2018-11-01 00:00:00
abstract::The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9338
更新日期:2018-11-01 00:00:00
abstract::The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9394
更新日期:2018-11-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC rema...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9391
更新日期:2018-11-01 00:00:00
abstract::Metastatic spread of gastric carcinoma to the breast is rare. In previous decades, reports on this subject were minimal and primarily limited to case reports. At present, little is known on the clinicopathological features and prognosis of this condition, and breast metastasis remains a challenging clinical problem. A...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9383
更新日期:2018-11-01 00:00:00
abstract::Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical n...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9463
更新日期:2018-11-01 00:00:00
abstract::Sigma-1 receptor (sigma-1R), a 25-kDa integral membrane protein, is expressed at a high density in various tumor cell lines and its ligands mediate tumor cell proliferation. However, the effect of this receptor on proliferation and the associated intracellular molecules in tumors remains unclear. The present study aim...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9448
更新日期:2018-11-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9497
更新日期:2018-11-01 00:00:00
abstract::Multiple myeloma (MM) is a hematological malignancy that lacks a cure. However, novel combination therapy is a current anti-MM strategy. Doxorubicin (DOX) is a type of anthracycline which is a first-line chemotherapeutic for treating MM and induces senescence in many types of cancer. Dinaciclib is a potent, small mole...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9474
更新日期:2018-11-01 00:00:00
abstract::Breast cancer is a common malignant tumor among females, with triple-negative breast cancer being an important type accounting for 15-20% of all breast cancer cases. Triple-negative breast cancer is one of the most aggressive types of cancer without standard adjuvant chemotherapy. Ganoderic acid A (GA-A) is one of the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9475
更新日期:2018-11-01 00:00:00
abstract::Liquid biopsies of circulating tumor DNA (ctDNA) can detect molecular alterations, including tumor-specific mutations, and have recently been used as a non-invasive diagnostic, prognostic, and predictive tool. However, this technique is not commonly used in the gynecological field. Gene mutation profiling of liquid bi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9467
更新日期:2018-11-01 00:00:00
abstract::Imaging techniques of upper tract urothelial carcinoma (UTUC) are presently limited. Upconversion particles (UCPs) could be used to target tumors for imaging. The present study aimed to assess the value of a nano-UCP as a diagnostic probe for deep tumor tissue, including UTUC. Polymer-coated water-soluble UCPs were sy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9430
更新日期:2018-11-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) show great promise as novel cancer biomarkers. Several studies have revealed an association between abnormal miRNA expression and the risk of various cancer types. However, the diagnostic accuracy and reliability of miRNAs remains unclear. The present meta-analysis was performed to summarize th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9489
更新日期:2018-11-01 00:00:00
abstract::The aim of this study was to discuss the antitumor effect of Tegafur combined with Barbadian on S-180 tumor-bearing mice. A murine tumor model was prepared by subcutaneous injection of S-180 sarcoma cells to the armpit of the right limb of healthy female SPF KM mice. The 24 tumor-bearing mice were randomly divided int...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9373
更新日期:2018-11-01 00:00:00
abstract::Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9415
更新日期:2018-11-01 00:00:00
abstract::Cyclin-dependent kinase inhibitor 2A (p16INK4a) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16INK4a in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9353
更新日期:2018-11-01 00:00:00
abstract::Effect of crizotinib on apoptosis of lung cancer cells was investigated. Human non-small cell lung adenocarcinoma H2228 cells were cultured in the presence of 0, 20, 40, 80, 160 and 320 nmol/l of crizotinib for 3 days, respectively. The inhibition rate of cell proliferation was measured by MTT assay, and half maximal ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9387
更新日期:2018-11-01 00:00:00
abstract::Protease-activated receptor 4 (PAR4), a member of the G-protein-coupled receptor family, was previously identified to be involved in the progression of cancer. Previous study revealed that the expression of PAR4 was increased in colorectal cancer tissues compared with the associated normal tissues, particularly in pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9407
更新日期:2018-11-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy affecting pediatric and adult populations. Although the outcomes of ALL in children have improved markedly in previous years, limited treatment strategies are available at present for adult patients with ALL. Wee1 is a crucial cell cycle checkp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9291
更新日期:2018-10-01 00:00:00
abstract::The S100 protein family is widely involved in the pathological process of various types of cancer. However, the prognostic value of the S100 protein family member S100A12 in hepatocellular carcinoma (HCC) remains unknown. A total of 139 patients undergoing curative surgical resection for HCC from December 2005 to June...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9270
更新日期:2018-10-01 00:00:00
abstract::The primary factor associated with poor survival rate in patients with colorectal carcinoma (CRC) is the presence of metastasis. The underlying molecular mechanisms of CRC metastasis are yet to be fully elucidated. The present study investigated the function of heat shock protein 27 (Hsp27) on the invasion and prolife...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9286
更新日期:2018-10-01 00:00:00
abstract::The present study evaluated the association between programmed cell death ligand-1 (PD-L1) expression and long-term oncologic outcomes in colorectal cancer (CRC). PD-L1 expression was evaluated using immunohistochemistry in 175 patients who underwent surgical resection for CRC between September 1999 and August 2004. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9264
更新日期:2018-10-01 00:00:00
abstract::The objective of the present study was to investigate the association between zinc finger protein (ZNF) 689 expression and the clinicopathological features and prognosis of hepatocellular carcinoma (HCC). A total of 102 paired HCC and paired non-cancerous tissues, and 16 normal liver tissues were collected. ZNF689 exp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9295
更新日期:2018-10-01 00:00:00
abstract::Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9322
更新日期:2018-10-01 00:00:00
abstract::High-fat diet induced obesity was associated with more aggressive prostate cancer. Recent research has demonstrated that integrin-linked kinase (ILK), β-parvin and downstream cofilin 1 jointly affected cancer progression. Meanwhile, these proteins were also involved in energy metabolism. Therefore, the present study w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9276
更新日期:2018-10-01 00:00:00
abstract::A nitroxide radical, Tempol (Tempol, TPL), is usually used as an antioxidative agent clinically, whereas the mechanism underlying its pro-oxidative effect has not been thoroughly investigated. The present study investigated the pro-oxidative effect of TPL on the inhibition of cellular proliferation and its role in enh...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9289
更新日期:2018-10-01 00:00:00
abstract::Endometrial cancer (EC) is the most commonly diagnosed gynecological malignancy in Australian women. Notably, its incidence and mortality rate is increasing. Despite this, there are limited treatment options for EC. Galectin-7 regulates tumorigenesis in numerous epithelial cancer types, but the role of galectin-7 has ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9193
更新日期:2018-10-01 00:00:00